Angiotensin-converting-enzyme inhibitors versus steroids as first-line drug treatment in Duchenne muscular dystrophy.
نویسندگان
چکیده
St phane Chabrier, Isabelle Desguerre, M lanie Porte, Claude Payet, FranÅois Rivier for the Neuromuscular Commission of the Soci t FranÅaise de Neurologie P diatrique 1 CHU Saint-Etienne, Service de m decine physique et r adaptation p diatrique – Centre de r f rence maladies neuromusculaires Rh ne-Alpes, H pital Bellevue, Sainttienne, France. 2 Unit de neurop diatrie – Centre de r f rence maladies neuromusculaires Garches-Necker-Mondor-Hendaye, H pital Necker, Paris, France. 3 INSERM, U841 Mondor Biomedical Research Institute, Universit Paris 12, Cr teil, France. 4 CHU N mes, Service de m decine physique et r adaptation – Centre de r f rence maladies neuromusculaires du grand Sud Ouest, H pital Caremau, N mes, France. 5 CHU Montpellier, Service de neurop diatrie – Centre de r f rence maladies neuromusculaires du grand Sud Ouest, H pital Gui de Chauliac, Montpellier, France. 6 INSERM, ERI 25 'Muscle et Pathologies', Universit Montpellier 1, UFR de M decine, Montpellier, France. Correspondence to: [email protected]
منابع مشابه
Effects of steroids and angiotensin converting enzyme inhibition on circumferential strain in boys with duchenne muscular dystrophy: a cross-sectional and longitudinal study utilizing cardiac magnetic resonance imaging
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Background Duchenne (DMD) and Becker (BMD) muscular dystrophies ( MD) are inherited X-linked diseases characterized by absence or decrease of dystrophin, a sarcolemal protein that is essential for maintenance of the muscular membrane integrity during muscular contraction. Cardiac involvement is as high, it can be clinically silent, but is often complicated by severe heart failure and high morta...
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BACKGROUND Duchenne muscular dystrophy (DMD), an X-linked disorder due to lack of dystrophin, is associated with muscle weakness and myocardial dysfunction. Although preliminary data support the efficacy of angiotensin-converting enzyme inhibitors on left ventricular (LV) function, our aim was to examine the long-term impact of a preventive treatment with perindopril on mortality in children wi...
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BACKGROUND Steroid use has prolonged ambulation in Duchenne muscular dystrophy (DMD) and combined with advances in respiratory care overall management has improved such that cardiac manifestations have become the major cause of death. Unfortunately, there is no consensus for DMD-associated cardiac disease management. Our purpose was to assess effects of steroid use alone or in combination with ...
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Neuromuscular Diseases are a heterogeneous molecular, clinical and prognosis group. Progress has been achieved in the understanding and classification of these diseases.Cardiac involvement in neuromuscular diseases namely conduction disorders, ventricular dilatation and dilated cardiomyopathy with its impact on prognosis, is often dissociated from the peripheral myopathy. Therefore, close surve...
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عنوان ژورنال:
- Developmental medicine and child neurology
دوره 52 11 شماره
صفحات -
تاریخ انتشار 2010